Table 3.
COG functional analysis between patients with MI and HC.
| Functions | Healthy group | MI group | Regulation in MI group |
|---|---|---|---|
| RNA processing and modification | 0.012 | 0.014 | Up-regulated |
| Chromatin structure and dynamics | 0.035 | 0.037 | Up-regulated |
| Energy production and conversion | 6.050 | 6.051 | Up-regulated |
| Cell cycle control, cell division, chromosome partitioning | 1.124 | 1.104 | Down-regulated |
| Amino acid transport and metabolism | 9.523 | 9.563 | Up-regulated |
| Nucleotide transport and metabolism | 3.257 | 3.169 | Down-regulated |
| Carbohydrate transport and metabolism | 6.758 | 6.840 | Up-regulated |
| Coenzyme transport and metabolism | 4.744 | 4.676 | Down-regulated |
| Lipid transport and metabolism | 3.364 | 3.340 | Down-regulated |
| Translation, ribosomal structure, and biogenesis | 7.785 | 7.559 | Down-regulated |
| Transcription | 6.922 | 6.895 | Down-regulated |
| Replication, recombination, and repair | 5.219 | 5.113 | Down-regulated |
| Cell wall/membrane/envelope biogenesis | 6.347 | 6.249 | Down-regulated |
| Cell motility | 1.418 | 1.453 | Up-regulated |
| Posttranslational modification, protein turnover, chaperones | 3.632 | 3.668 | Up-regulated |
| Inorganic ion transport and metabolism | 5.047 | 5.127 | Up-regulated |
| Secondary metabolites biosynthesis, transport, and catabolism | 1.625 | 1.659 | Up-regulated |
| General function prediction only | 11.625 | 11.70 | Up-regulated |
| Function unknown | 7.257 | 7.432 | Up-regulated |
| Signal transduction mechanisms | 4.019 | 4.095 | Up-regulated |
| Intracellular trafficking, secretion, and vesicular transport | 2.222 | 2.259 | Up-regulated |
| Defense mechanisms | 2.001 | 1.974 | Down-regulated |
| Extracellular structures | 0.427 | 0.268 | Down-regulated |
| Cytoskeleton | 0.426 | 0.464 | Up-regulated |
The average relative abundance of COG pathway and significant difference were verified with a Wilcoxon signed-rank test in GraphPad Prism and p <0.05 suggests significant variance between both the groups.