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. 2022 May 23;19(6):1892–1905. doi: 10.1021/acs.molpharmaceut.2c00032

Figure 4.

Figure 4

LNP protein expression profile and statistical analysis from BBD experiments (Iteration B). (A) Box plot displaying protein expression (RLU) as a function of ionizable lipid type. (B) Response surface plot for protein expression for LNP containing ALC-0315 ionizable lipid. (C) Response surface plot for protein expression for LNP containing SM-102. Heat map plot displaying Spearman correlation’s coefficient (D) and p-values (E) between CQAs. LNPs containing MC3 ionizable lipid are excluded from the protein expression analysis in B–E due to low expression levels.