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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Neuropharmacology. 2022 Mar 25;210:109046. doi: 10.1016/j.neuropharm.2022.109046

Fig. 5.

Fig. 5.

Effects of alcohol extinction and intermittent footshock stress on the gene expression of Crhr1, Hcrtr1, and Hcrtr2. (A) Rats acquired alcohol self-administration over the 21 training sessions. (B) Extinction of alcohol-seeking behavior over the 10 extinction sessions. (C) Stress increased Crhr1 mRNA expression compared with extinction and naive rats but decreased following extinction. (D) Increase in Hcrtr1 mRNA expression following extinction and stress. (E) Increase in Hcrtr2 mRNA expression by stress. The data are expressed as mean + SEM. ***p < 0.001, vs. inactive lever; +p < 0.05, vs. extinction (EXT). *p < 0.05, vs. naive.