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. 2022 May 30;19(1):751–763. doi: 10.1080/15476286.2022.2079889

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — DARS-AS1 and DARS bind to METTL3 and METTL14. A GEPIA 2 database analysed the correlation between METTL3 and DARS expression and between METTL14 and DARS expression in CC tissues. B Expressions of METTL3 and METTL14 were detected in HeLa cells treated with normoxia or hypoxia. C-D RIP and RNA pull down assays assessed the combination of DARS-AS1/DARS with METTL3/METTL14. E RNA pull down experiments were carried out for evaluating the combination of DARS-AS1 and METTL3/MATTL14. F RNA pull down experiments were carried out for evaluating the combination of DARS 3ʹUTR and METTL3/MATTL14. G RIP experiments were performed for investigation into impact of DARS-AS1 knockdown on binding between DARS 5ʹUTR and METTL3 or MATTL14. Experimental procedures were repeated independently for three times. **P < 0.01.