Table 2.
Brain response to air-puff stimulation
| Side | Size (mm3) | Location (MNI, mm) | Obex (mm) | Z-score | Z-score | P-value (HC vs. MIG) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | HC | MIG | ||||||
| Cortical areas | ||||||||||
| Posterior/middle insula (pINS) | L | 14152 | −36 | −28 | 10 | 6.09 | 2.49±2.05 | 3.04±1.96 | 0.21 | |
| R | 10872 | 42 | −20 | 6 | 6.00 | 2.59±2.01 | 3.42±1.93 | 0.24 | ||
| Secondary somatosensory cortex (SII) | L | 14152 | −64 | −22 | 22 | 4.58 | 1.39±1.28 | 1.48±1.87 | 0.87 | |
| R | 10872 | 58 | −28 | 14 | 4.62 | 2.60±2.70 | 3.07±3.25 | 0.66 | ||
| Supramarginal gyrus (SMG) | L | 14152 | −64 | −36 | 34 | 4.35 | 1.07±1.03 | 0.84±1.13 | 0.56 | |
| R | 10872 | 62 | −40 | 38 | 3.71 | 1.15±1.32 | 1.12±1.67 | 0.95 | ||
| Subcortical areas | ||||||||||
| Hypothalamus (Hyp) | L | 408 | −2 | −4 | −8 | 4.26 | 1.10±0.98 | 1.02±1.39 | 0.84 | |
| Caudate nucleus (Caud) | R | 272 | 20 | −4 | 22 | 3.50 | 0.84±1.16 | 0.72±1.10 | 0.77 | |
| Putamen (Put) | R | 136 | 24 | 0 | 10 | 2.96 | 0.44±1.17 | 0.38±0.84 | 0.87 | |
| Brainstem | ||||||||||
| Spinal trigeminal nucleus (Sp5) | L | 88 | −10 | −34 | −42 | +19 | 3.37 | 0.70±1.14 | 0.62±0.94 | 0.83 |
| R | 160 | 12 | −36 | −40 | +21 | 3.00 | 0.56±1.12 | 0.60±0.96 | 0.92 | |
| Pontine nucleus | L | 8 | −12 | −26 | −44 | +17 | 2.47 | 0.26±0.91 | 0.85±1.16 | 0.12 |
| R | 72 | 10 | −20 | −44 | +17 | 3.47 | 1.02±1.48 | 0.69±1.03 | 0.47 | |
| Periaqueductal gray (PAG) | - | 184 | 0 | −32 | −12 | +49 | 3.81 | 0.78±0.77 | 0.73±1.20 | 0.88 |
Data are shown as mean±STD. HC = Healthy Controls; MIG = Migraine Patients; L = Left side (contralateral to stimulation); R = Right side (ipsilateral to stimulation). Distance from obex was estimated after rotating the brainstem image into upright position.