Table 3.
Amplification of Sp5 activation and habituation to ophthalmic nerve somatosensory stimulation
| Side | Amplification ratio | P-value (HC vs. MIG) | HC (linear fit) | MIG (linear fit) | P-value (HC vs. MIG) | ||||
|---|---|---|---|---|---|---|---|---|---|
| HC | MIG | Slope | r (P) | Slope | r (P) | ||||
| Cortical areas | |||||||||
| Posterior/middle insula (pINS) | L | 1.02±0.80 | 2.99±0.50 | <0.05 | −0.03±0.01* | −0.70 (<0.05) | −0.02±0.01 | −0.53 (<0.01) | 0.36 |
| R | 1.14±0.83 | 3.02±0.62 | 0.06 | −0.05±0.01** | −0.85 (<0.001) | −0.00±0.01 | −0.11 (0.76) | <0.05 | |
| Secondary somatosensory cortex (SII) | L | 0.83±0.72 | 0.47±0.52 | 0.52 | −0.08±0.01** | −0.92 (<0.0001) | −0.06±0.01**** | −0.78 (<0.01) | 0.55 |
| R | 1.85±1.35 | 3.16±1.94 | 0.23 | −0.09±0.02*** | −0.93 (<0.0001) | −0.07±0.02** | −0.85 (<0.001) | 0.38 | |
| Supramarginal gyrus (SMG) | L | 0.51±0.38 | 0.26±0.49 | 0.53 | −0.05±0.02* | −0.76 (<0.01) | −0.05±0.02* | −0.63 (<0.05) | 0.81 |
| R | 0.77±0.56 | 1.04±0.87 | 0.56 | −0.06±0.02* | −0.69 (<0.05) | −0.08±0.02** | −0.77 (<0.01) | 0.55 | |
| Subcortical areas | |||||||||
| Hypothalamus (Hyp) | L | 0.93±0.26 | 1.84±0.40 | <0.05 | 0.00±0.01 | 0.02 (0.94) | −0.02±0.01 | −0.28 (0.40) | 0.34 |
| Caudate nucleus (Caud) | R | 0.59±0.18 | 0.43±0.19 | 0.47 | −0.01±0.01 | −0.44 (0.18) | −0.01±0.01 | −0.33 (0.32) | 0.99 |
| Putamen (Put) | R | 0.30±0.23 | 0.20±0.14 | 0.49 | −0.03±0.01* | −0.62 (<0.05) | −0.02±0.01 | −0.52 (0.10) | 0.71 |
| Brainstem | |||||||||
| Spinal trigeminal nucleus (Sp5) | L | n/a | n/a | n/a | 0.01±0.02 | 0.45 (0.17) | 0.00±0.01 | −0.04 (0.90) | 0.57 |
| R | n/a | n/a | n/a | 0.00±0.01 | −0.08 (0.81) | −0.01±0.01 | −0.29 (0.38) | 0.79 | |
| Pontine nucleus | L | n/a | n/a | n/a | 0.02±0.02 | 0.34 (0.31) | 0.01±0.01 | 0.15 (0.65) | 0.75 |
| R | n/a | n/a | n/a | 0.02±0.02 | 0.27 (0.42) | 0.01±0.01 | 0.19 (0.58) | 0.64 | |
| Periaqueductal gray (PAG) | - | n/a | n/a | n/a | 0.00±0.01 | 0.02 (0.96) | −0.01±0.01 | −0.39 (0.24) | 0.50 |
Data are shown as mean±SEM. Habituation (bold italicized) defined by negative slope significantly different from nil, and significant linear fit (r-coefficient). HC = Healthy Controls; MIG = Migraine Patients; L = Left side (contralateral to stimulation); R = Right side (ipsilateral to stimulation); Slope: change in activation (%-change) per stimulus block; r = correlation coefficient. Habituation slope is different from nil: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.