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[Preprint]. 2022 Jun 7:rs.3.rs-1354127. [Version 2] doi: 10.21203/rs.3.rs-1354127/v2

Figure 3. Discovery of interactome-based host-targeting therapies for COVID-19.

Figure 3.

(a) Workflow of drug repurposing for COVID-19 using our interactome. We ranked the drugs by their proximity to the SARS-CoV-2 host factors (Table S7), filtered the top drugs by their NCATS anti-SARS-CoV-2 profiles (Table S8), and finally analyzed their drug-outcome relationship using electronic health records (EHR) data (Table 1, Table S9–S10). (b) The top 23 drugs can target the SARS-CoV-2 host factors directly or through protein-protein interactions with their targets.