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Synthesis of diosgenin–benzoic acid mustard trihybrids 8−10. Reagents and conditions: (a) ethylene oxide, H2O, CH3COOH, rt, 24 h; (b) POCl3, 50 °C, 0.5 h; (c) 10% HCl, 12 h; (d) Ac2O, dry pyridine, dry CH2Cl2, rt, 6 h; (e) NaBH3CN, AcOH, CH2Cl2, rt, 8 h; (f) KOH, CH3OH, rt, 6 h; (g) (h) Benzoic acid mustard, EDCI, DMAP, CH2Cl2, rt, 24 h.
