Fig. 1. Graphic outline of KPMP data integration and harmonization procedures.

The “subway map” representation of the experimental and analytical protocols used within KPMP is shown in operational flow from kidney biopsy to the integrated multimodal data represented in this manuscript. The kidney biopsy, which is processed through three different tissue processing methods, is shared among tissue interrogation sites (TISs) that generate the data. Four key modalities of molecular data are generated: transcriptomic (red), proteomic (blue), imaging (yellow), and metabolomic (green). Biopsy cores 2 and 3 are used for the molecular analysis; biopsy core 1 (not depicted) is used for histological analysis.