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. 2022 Jun 8;8(23):eabn4965. doi: 10.1126/sciadv.abn4965

Fig. 5. Enrichment analysis of markers for PT and glomerular cells and segments predicts well-known cell functions.

Fig. 5.

(A) Marker genes and proteins of each PT cell subtype or subsegment were subjected to dynamic enrichment analysis using the MBCO. SCPs that were among the top seven predictions were connected by dashed lines, if their interaction was part of the top 25% inferred MBCO SCP interactions, and by dotted lines, if their functional relationship was curated from the literature. Figure S8 shows additional predicted SCPs involved in cell adhesion and translation. Metabolites associated with nonglomerular compartments were subjected to MetaboAnalyst enrichment analysis (fig. S6). Any pathway among the top eight predicted pathways that was predicted on the basis of metabolites specifically for that pathway was mapped to MBCO SCPs, if possible, and integrated into the PT SCP network. MBCO SCPs carnitine shuttle and carnitine biosynthesis and transport were added to the predicted MetaboAnalyst pathways since four and two involved metabolites were among the nonglomerular metabolites (see Methods for details). (B) HumanBase analysis of PT marker genes and proteins.