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. 2022 Jun 8;8(23):eabn4965. doi: 10.1126/sciadv.abn4965

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Fig. 8. — (A) Matrix-assisted laser desorption/ionization mass spectrometry imaging reveals that the ion distribution of SM d18:1/16:0, [M + Na]⁺, correlates with the glomerular kidney regions. (B) Podocytes express two genes involved in sphingomyelin synthesis including the genes CERS6 that is identified by both sn and sc RNAseq datasets and the LMD RNAseq dataset. CERS6 specifically generates C16 ceramides, the direct precursor for SM d18:1/16:0. (C) CERS6 is also expressed in mesangial cells, although only detected by the sn RNAseq dataset. Glomerular expression of the gene SERINC2 is detected by the LMD RNAseq assay.