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. 2022 Jun 8;8(23):eabn5345. doi: 10.1126/sciadv.abn5345

Fig. 7. Cross-talk between central GLP-1 signal and pancreas mediates glucose-lowering effects.

Fig. 7.

(A) Descending controls of NTSGLP-1–DMHGLP-1R–DMV–pancreas activity affect glucose level. (B) GLP-1 binding to GLP-1R increases intracellular cAMP levels, followed by suppression of voltage-gated potassium currents, inducing a depolarization of the postsynaptic neuron.