Fig. 8. TCR-mediated anti-CD3/CD28 beads stimulation of CAR T cells fails to predict clinical responses.

(A) Coexpressed cytokine modules identified in TCR-mediated stimulation. Genes are ordered by hierarchical clustering. (B) An integrated cytokine module representation UMAP. Cells are colored by responsive states, and UMAPs are split by experimental conditions. (C) The distribution of the identified modules on the UMAP. (D) Quantification of identified modules among CR, NR, and RL patients. The P values were calculated with Mann-Whitney test.