Table 2.

Clinical and histological findings of dysplastic and macroregenerative nodules

Case	Specimen	Age	M/F	Liver disease	Fibrosis	Size (cm)	Diagnosis	Immuno-histochemistry
1	Liver explant	58	M	Cryptogenic	cirrhosis	0.9	Macro-regenerative nodule	Ki67, less than 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
2	Liver explant	20	M	PSC-AIH overlap	Bridging fibrosis to cirrhosis	0.5	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
3	Liver explant	20	M	PSC-AIH overlap	Bridging fibrosis to cirrhosis	0.4	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
4	Liver explant	20	M	PSC-AIH overlap	Bridging fibrosis to cirrhosis	0.5	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
5	Liver explant	62	M	Chronic hepatitis C and a focus of well diff HCC	Cirrhosis	0.8	Macro-regenerative nodule	Ki67, 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
6	Liver explant	64	M	Steatohepatitis and multifocal HCC	cirrhosis	0.9	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic intact Bcat negative
7	Liver explant	64	M	Steatohepatitis and multifocal HCC	cirrhosis	0.5	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic focal equivocal loss Bcat negative
8	Liver explant	64	M	Steatohepatitis and multifocal HCC	cirrhosis	0.6	Dysplastic nodule, low grade	Ki67, 1% GP3 negative GS negative AFP negative Retic focal equivocal loss Bcat negative

GP3: Glypican 3

AFP: alpha fetoprotein

Bcat: beta catenin nuclear staining

GS: glutamine synthetase

Retic: reticulin

PSC: Primary sclerosing cholangitis

AIH: Autoimmune hepatitis

HCC: Hepatocellular carcinoma