FIGURE 5.

Simulated drug concentration with different vessel wall pore diameters. A sagittal view in the center of tumor tissue showing the spatial distribution of drug concentration for 2 × 10⁻¹³ m²/(Pa s) hydraulic conductivity of the tumor interstitial space, for different diameters of the therapeutic agent, D_s: 1, 20, and 60 nm in three snapshot: 6, 12, and 24 h, and for different pore diameters of tumor vessel walls, D_o: (A) 50 nm and (B) 150 nm. Drug concentration is normalized by division with the reference value entering the catheter.