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Average drug concentration as a function of the time for different vessel wall pore diameters. Average relative drug concentration in tumor tissue as a function of time for different diameters of therapeutic agents, Ds, for 2 × 10−13 m2/(Pa s) hydraulic conductivity of the tumor interstitial space, and for different pore diameters of tumor vascular walls, Do: (A) 50 nm and (B) 150 nm. Drug concentration is normalized by division with the reference value entering the catheter.
