Table 7.

Mutational signatures in each sample (N = 15 samples from cohort 2 with whole-exome sequencing), based on bladder-specific signatures in the COSMIC v2 database. Mutational signatures represent global patterns in the types of single-nucleotide changes throughout the genome and are thought to reflect distinct underlying mutational processes. The numbers indicate the percent of mutations attributed to each signature within each sample.

Sample	Signature.1	Signature.2	Signature.5	Signature.10	Signature.13
GP012	0.01943257	0.36660802	0.149879	0.02486539	0.43921502
GP043	0.01095983	0.33135712	0.34225969	0.02093894	0.29448443
GP003	3.28E-18	0.05226691	0.9015513	0	0.04618179
GP025	0.0391949	0.43356456	0.14695689	0.00935119	0.37093247
GP023	0.17884431	0.28888586	0.17462784	0.04510776	0.31253424
GP011	0.01690564	0.31356415	0.27458071	0	0.39494949
GP016	0.04755421	0.09875741	0.84644402	0	0.00724437
GP034	0.02233931	0.202452	0.61821754	-8.67E-19	0.15699115
GP007	0.01140029	0.43952321	0.09374151	0.03198736	0.42334762
GP018	0.00392937	0.54435374	0.07943001	0.03159905	0.34068783
GP032	0.09088163	0.05547802	0.76846216	0	0.08517819
GP013	0.03954119	0.00325378	0.59572065	0	0.36148437
GP005	0.00370014	0.1725524	0.53444981	0	0.28929765
GP030	0.04876071	0.25637049	0.54555192	0.05520981	0.09410708
GP009	0	0.22447006	0.309945	0.03486223	0.4307227