Figure 5. R-nanoCHOP improves overall survival compared to R-CHOP in DLBCL PDX-bearing NSG mice.
22 NSG mice were implanted with DLBCL PDX tumor (S8B) and randomized to two groups. After death of one animal prior to engraftment, remaining animals were treated with R-CHOP (n=11) or R-nanoCHOP (n=10) once on day 1 of every 21 days. Predetermined survival endpoints were tumor volume ≥ 1500 mm3, weight loss > 20%, or other signs of morbidity. A) Average tumor volume ±SEM measured twice weekly via ultrasound. B) Average daily body weight ±SEM of surviving animals. C) Overall survival of all treatment groups. ****P < 0.0001 (Mantel-Cox). A-C are mean ±SEM of at least ten technical replicates representative of one independent experiment.