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. 2022 May 16;11:e72512. doi: 10.7554/eLife.72512

Figure 7. Anti-proliferative activities of selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders/downregulators (SERDs) in MCF7 cells with heterozygous WT/Y537S ESR1.

Figure 7.

(A) 4-hydroxytamoxifen (4OHT). (B) Fulvestrant (ICI). (C) Lasofoxifene (Laso). (D) Lasofoxifene-Stabilizer (LA-Stab). (E) Lasofoxifene-Degrader (LA-Deg). (F) Normalized cell count after 84 hr. All antagonist treatments are in the presence of 1 nM estradiol (E2). All data are normalized to initial cell count of the vehicle wells in their respective plates. All data are mean ± SEM for three biological replicates and a total of nine technical replicates.