Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 25;13:866590. doi: 10.3389/fphys.2022.866590

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Schiffer, Löf, Gallini, Kamali-Moghaddam, Carlström and Palm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Inhibitor order specific ANT- and UCP-dependent leak respiration were measured in isolated rat kidney mitochondria and defined as the change in leak respiration by adding the ANT specific inhibitor CATR locking ANT into c-conformation and the UCP inhibitor GDP during mitochondrial leak state in presence of pyruvate, malate and oligomycin. Before ANT and UCP inhibition, leak mediated respiration was induced by arachidonic acid. The order of inhibition is stated underneath the x-axis. (A) Inhibitor order specific ANT and UCP dependent leak respiration using CATR and GDP. (B) In a separate experiment with similar conditions, ANT inhibitor BKA (locking ANT in m-conformation) was used.