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. 2022 Jun 1;30(2):157–167. doi: 10.53854/liim-3002-1

Figure 4.

Figure 4

Immunohistochemical study of SARS-CoV-2 placental tissue.

(A): Showing staining for SARS-CoV-2 spike protein. (B): Immunostaining for nucleocapsid proteins, showing stronger and more positivity than spike protein. Inset with arrow showing Hofbauer cell. (C): Showing double staining for spike protein (brown) and CD14 (blue), mainly at the sites where viral protein is expressed more intensely. (D): Showing staining for CD66b (blue) for neutrophils and CD14 (brown) expression for monocyte macrophages in the intevillous space (IVS) with presence of CD14 Hofbauer cells in the villi. (Courtesy: Facchetti F, Bugatti M., et al. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta. EBioMedicine. 2020 Sep; 59, 102951).