Table 4. Univariate and multivariate Cox proportional hazard model for overall PFS.

Variable	N	Event N	Univariate				Multivariate
			HR	95% CI	P value		HR	95% CI1	P value
Gender					0.022				0.018
Male	106	62	–	–			–	–
Female	37	15	0.53	0.30–0.94			0.41	0.19–0.89
Age category					0.563
<65 years	97	49	–	–
≥65 years	45	27	1.15	0.72–1.84
Pathological type					0.328
ccRCC	120	63	–	–
Non-ccRCC	15	8	1.48	0.70–3.12
Maximum tumor size (cm)					0.330
<7	47	27	–	–
≥7	52	28	0.77	0.45–1.31
IMDC risk factors					<0.001				0.005
0	46	21	–	–			–	–
1	60	28	1.69	0.92–3.10			20.4	3.76–110.00
2	37	28	4.03	2.16–7.52			16.7	3.38–82.40
Local treatment					0.112
No	100	54	–	–
Yes
Primary site	14	4	0.39	0.14–1.08
Metastasis site	22	17	0.94	0.53–1.68
Baseline relapse/metastasis					0.012
No	10	6	–	–
Yes—single metastasis
Lung	44	18	0.42	0.17–1.07
Bone	9	5	0.77	0.24–2.55
Others	19	11	0.34	0.12–0.98
Yes—multiple metastases
Including lung	44	22	0.72	0.29–1.79
Excluding lung	17	15	1.3	0.50–3.37
Number of R/M location					0.007
No relapse/metastasis	10	6	–	–
Single	72	34	0.42	0.18–1.03
Multiple	61	37	0.88	0.37–2.10
Baseline number of R/M organs					0.008				0.004
0	10	6	–	–			–	–
1	72	34	0.42	0.17–1.02			0.17	0.05–0.53
2	39	23	0.75	0.30–1.85			0.39	0.12–1.27
≥3	22	14	1.24	0.47–3.24			0.55	0.16–1.87
Baseline GRAN					0.214
Normal	114	61	–	–
Abnormal	7	5	1.89	0.75–4.77
Baseline lymphocyte					0.245
Normal	99	55	–	–
Abnormal	22	11	1.5	0.78–2.91
Baseline eosinophil					0.007				0.736
Normal	103	51	–	–			–	–
Abnormal	18	15	2.38	1.32–4.27			1.16	0.49–2.71
Baseline PLT					0.489
Normal	104	52	–	–
Abnormal	17	14	1.24	0.68–2.26
Baseline hemoglobin					0.023				0.669
Normal	83	39	–	–			–	–
Abnormal	38	27	1.8	1.10–2.97			1.19	0.54–2.59
Baseline LDH					0.011				0.598
Normal	80	37	–	–			–	–
Abnormal	41	29	1.94	1.17–3.20			0.82	0.39–1.72
Baseline calcium					0.512
Normal	90	50	–	–
Abnormal	31	16	1.21	0.69, 2.15
Baseline creatine					0.169
Normal	93	49	–	–
Abnormal	28	17	1.5	0.86, 2.64
Baseline BUN					0.968
Normal	87	46	–	–
Abnormal	34	20	0.99	0.58, 1.68
Urine protein					0.379
Normal	101	58	–	–
Abnormal	19	7	0.71	0.32–1.57

PFS, progression-free survival; ccRCC, clear cell renal cell carcinoma; IMDC, International Metastatic renal cell carcinoma Database Consortium; HR, hazard ratio; R/M, relapse/metastasis; GRAN, Granulocytes; PLT, platelet; LDH, lactate dehydrogenase; BUN, blood urea nitrogen; CI, confidence interval.