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. 2022 May 19;606(7913):389–395. doi: 10.1038/s41586-022-04735-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Number of mutations (synonymous and non-synonymous), homozygous deletions, heterozygous deletions and copy number neutral loss of heterozygosity (LOH) changes in HLA class-I pathway genes (B2M, CANX, CALR, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, TAP1, TAP2, TAPBP, ERAP1, ERAP2, HSPA5, PDIA3, SAR1B, SEC13, SEC23A, SEC24A, SEC24B, SEC24C, SEC24D, SEC31A) in primary and recurrent PDACs. (b) mRNA expression in HLA class-I pathway genes by bulk RNA sequencing (ICGC, TCGA cohorts) and transcriptional analysis (Affymetrix, Memorial Sloan Kettering Cancer Center (MSKCC) cohort) in primary PDAC tumours. (c) Representative multiplexed immunohistochemical images (left) and ratio (right) of MHC-I⁺ tumour cells (CK19⁺) and MHC-I⁺ non-tumour cells (CK19^-) in STS and LTS primary PDACs. n = individual tumours. Horizontal bars = median. Horizontal bars on violin plots show median and quartiles. P value by Wald’s test adjusted for multiple comparison testing.

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