Extended Data Fig. 4. TCR transduction and antigen specificity.

(a) Experimental schema to transduce and measure ${\mathbf{p}}^{\text{WT}}$-specific T cell receptor (TCR) activation. hVα,β = human α and β variable regions; mCα,β = mouse α and β constant regions. (b) Representative gating strategy to detect transduced TCR activation and specificity. (c–e) Sequences of model ${\mathbf{p}}^{\text{WT}}$s and ${\mathbf{p}}^{\text{WT}}$-specific TCRs, and TCR activation across varied ${\mathbf{p}}^{\text{WT}}$concentrations.

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