Extended Data Fig. 2. Distribution of somatic mutations within driver genes (previous page).

Lolliplots show the longest protein isoform of each gene, with protein domains depicted by grey rectangles. Each circle represents a somatic mutation. The vertical distance of the circle from the protein cartoon indicates its recurrence in the cohort (quantified on the y-axis). Amino acid codons recurrently mutated (ie. observed in more than one individual) in our cohort are explicitly labelled. Circle colours indicate the mutation type as per key. Non-truncating mutations (missense, inframe, synonymous) are depicted above and truncating mutations (nonsense, frameshift) below the protein cartoon.