Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 13;606(7913):368–374. doi: 10.1038/s41586-022-04597-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — a–c, Subgroup reservoir analysis for Group 1 participants that interrupted ART (ATI+bNAb n = 10) (a), for Group 1 and 4 additional participants from a corresponding NIH/NIAID clinical trial (ATI+bNAb Group 1 plus NIH pt., n = 14) (b), and Group 2 participants that remained on ART (ART+bNAb, n = 6) during bNab therapy (c). Left panels show the frequency of intact and defective proviral genomes per 10⁶ CD4+ T cells (log normalized) as determined by Q4PCR pre-therapy and post-therapy (24–26 weeks). Open symbols represent lower limit of detection (defined as half of intact proviral frequency assuming 1 intact proviral genome/total number of analysed cells without target identification). Scatter plots depict mean with SD. Statistical significance was determined using two-tailed paired Student’s t-test. Right panels show longitudinal changes in relative representation of proviral subtypes in the respective subgroups. Depicted are the fractions of intact and defective proviral subtypes relative to total proviruses recovered from each participant at the indicated time point. Proviral subtypes: Intact, SV, Structural Variation; MIG, Missing Internal Gene; LTR, LTR defects; MSD, Major Splice Donor mutation; NF, Non-Functional. Only participants for whom at least one intact proviral genome was recovered are shown (ATI+bNAb Group 1 n = 8; ATI+bNAb Group 1 plus NIH pt. n = 11, ART+bNAb Group 2 n = 6). Horizontal bars show median and interquartile range (IQR). Statistical significance was determined using two-tailed Wilcoxon matched-pairs signed rank test. d, Relative change in proviral frequencies between pre-therapy (T1) and post-therapy time points (T2) for intact (green) and defective (red) proviral frequencies for ATI+bNab Group 1 (left two columns), ATI+bNAb Group 1 plus NIH (middle two columns), and ART+bNab (right two columns) participants, respectively. Plotted values depict relative change with the black horizontal bars showing the median change. Statistical significance was determined using two-tailed Wilcoxon matched-pairs signed-rank test for matched comparisons within groups.