Fig. 3. Post hoc sensitivity analysis of reservoir and plasma rebound viruses and impact on time to viral rebound.

Latent reservoir (left) and plasma rebound viruses (right) from participants in group 1 (n = 16) were phenotypically and genotypically analysed for resistance to 10-1074 and 3BNC117, respectively (Methods). Sequence analysis was based on env sequences recovered by limiting-dilution PCR at baseline or by Q4PCR from all time points tested. The middle panel depicts time to viral rebound in ascending order. PhenoSense Monoclonal Antibody Assay antibody-sensitive (IC₉₀ < 1 μg ml⁻¹) and -resistant viruses (IC₉₀ > 1 μg ml⁻¹) are depicted with green and red squares, respectively. Sequence analysis of antibody-sensitive (absence of resistant viruses) or -resistant (identification of one or more resistant viruses) viruses are depicted in green and red squares, respectively. The number depicted in the squares represents the number of sequences analysed. Participant samples for which no results or sequences could be obtained are depicted in grey. Participants who maintained viral suppression without experiencing rebound are shown with a blue square. Samples that were not analysed are indicated with a white square.