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. 2022 Apr 13;606(7913):368–374. doi: 10.1038/s41586-022-04597-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Gating strategy used to define total CD4⁺ (blue) and CD8⁺ (red) T cells. Dump channel includes CD19, CD20, CD14 and CD66b as well as Live/Dead. CD4+ T cells are identified as Dump−CD14−CD3+CD4+, whereas CD8+ T cells are Dump−CD14−CD3+CD8+. b, Representative flow cytometry plots and frequencies of CD4⁺ T cells expressing CD38, CD69, CD71, CD25, CD152, CD279, TIGIT, CD223 and CD366. c, Representative flow cytometry plots and frequencies of CD8⁺ T cells expressing CD38, CD69, CD71, CD25, CD152, CD279, TIGIT, CD223 and CD366. Relative change in frequencies was assessed between pre-therapy (T1) and 26-week post-therapy time points (T2). All panels represent the mean ± SD of 11 different donors. Significance was determined by two-tailed paired Student’s t-test.