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. 2022 Apr 13;606(7913):368–374. doi: 10.1038/s41586-022-04597-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Comparison of time to viral rebound between Group 1 participants with genotypically 10-1074 resistant or sensitive reservoir viruses recovered by Q4PCR. Black line depicts median. Statistical significance was determined using a two-tailed unpaired t-test. b, Comparison of time to viral rebound between Group 1 participants with phenotypically resistant (n = 3), partially resistant (n = 5) or sensitive (n = 2) reservoir viruses to 3BNC117 and 10–1074 by PhenoSense. Black line depicts median. Statistical significance was determined using one-way ANOVA with Tukey multiple comparison test. c, Comparison of time to viral rebound between Group 1 that harbor clade B (n = 15) and non-clade B viruses (n = 2), respectively. Black line depicts median. Statistical significance was determined using a two-tailed unpaired t-test. d, Intact proviral frequency per 10⁶ CD4 T cells versus time of viral rebound in the Group 1 participants that remained suppressed after week 20 (n = 10). Graphs show the correlation at pre- (left) and post-therapy (right) time points, respectively. The r and P values were determined by two-tailed Pearson’s correlations.