Extended Data Fig. 5. Reservoir sequence analysis.

a, Pie charts depict the distribution of recovered intact and defective proviral sequences. Left pie chart shows the distribution of all 6915 recovered from 33 participants. Middle and right pie charts show the distribution for participants in the bNAb Therapy and ART alone groups, respectively. The number in the middle of the pie represents the total number of proviruses sequenced. Pie slices indicate the proportion of sequences that were intact or had different defects, including structural variation (yellow), missing internal genes (red), LTR defects (orange), MSD mutation (blue) and non-functional (pink). b, Graph depicts the paired measurements of the intact and defective proviral reservoir size in the bNAb Therapy (left panel) and ART alone (right panel) groups. Y-axis shows frequencies of intact or defective proviruses per 10⁶ CD4+ T cells. X-axis depicts time in weeks. Paired measurements with a relative decrease or increase are shown with a solid or dotted line, respectively. c, Pie charts depict the distribution of recovered intact and defective proviral sequences at pre- and post-therapy (bNAb Therapy group, left panel) or baseline and follow-up time point (ART alone group, right panel). The number in the middle of the pie represents the total number of proviruses sequenced. Only participants for whom at least one intact proviral genome was recovered are included (bNAb Therapy n = 14, ART alone n = 9).