Table 2.
Pharmacokinetic parameters for capecitabine and its metabolites (Mean ± SD).
| Parameter | Mean (S.D) |
|---|---|
| Capecitabine | |
| Tmax (h) | 1 (0.25) |
| Cmax (μg/mL) | 5.2 (1.3) |
| Clast (μg/mL) | 0.6 (0.23) |
| AUClast (μg.h/mL) | 28 (10) |
| Vdobs (l) | 186 (28) |
| Clobs (mL/min) | 775 (2 1 3) |
| MRTlast (h) | 1 (0.15) |
| t1/2 (h) | 2.7 |
| 5′-DFCR | |
| Tmax (h) | 1 (0.3) |
| Cmax (μg/mL) | 5.6 (2.1) |
| AUClast (μg.h/mL) | 37.15 (12) |
| 5′-DFUR | |
| Tmax (h) | 1 (0.25) |
| Cmax (μg/mL) | 6.4 (1.6) |
| AUClast (μg.h/mL) | 39.5 (13) |
| 5-FU | |
| Tmax (h) | 1 (0.35) |
| Cmax (μg/mL) | 1.26 (0.23) |
| AUClast (μg.h/mL) | 4.4 (2) |