Fig. 2.

Impact of LEV 50 mg/kg and Sod.Se 0.25 and 0.5 mg/kg alone and in combination on progression of PTZ-induced kindling process. The animals were injected with PTZ 30 mg/kg every other day for 21 days and observed for 30 min after each PTZ injection for seizure scoring according to Racine scale and severity was expressed (A) comparison of control, diazepam and LEV groups with PTZ control, (B) comparison of Sod.Se 0.25 and 0.5 vs PTZ control, (C) comparison of LEV + Sod.Se 0.25 and 0.5 with PTZ control. Statistical analysis was performed using the two-way ANOVA followed by Dunnett’s test and all values are expressed as mean ± S.E.M (n = 8). *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 for control vs PTZ control rats, ^#P < 0.05^{, ##}P < 0.01^{, ####}P < 0.001 and ^####P < 0.0001 for diazepam vs PTZ control, ^aP < 0.05, ^aaP < 0.01, ^aaaP < 0.001 and ^aaaaP < 0.0001 for LEV vs PTZ control, ^bP < 0.05 and ^bbP < 0.01 for Sod.Se 0.25 vs PTZ control, ^ccP < 0.01 and ^cccP < 0.001 for Sod.Se 0.5 vs PTZ control, ^ddP < 0.01, ^dddP < 0.001 and ^ddddP < 0.0001 for LEV + Sod.Se 0.25 vs PTZ control, ^eP < 0.05, ^eeP < 0.01, ^eeeP < 0.001 and ^eeeeP < 0.0001 for LEV + Sod.Se 0.5 vs PTZ control.