Fig. 4.

Assessment of anxiolytic impact of LEV and Sod.Se 0.25 and 0.5 mg/kg alone and in combination in PTZ-kindled rats. The animals were allowed to explore brightly illuminated arena and dark zone spontaneously by placing them in L/D box for 5 min and noted for (A) time spent in light zone and (B) time spent in dark zone. Statistical evaluation was performed by using one-way ANOVA followed by Dunnett’s test and data set was expressed in mean ± S.E.M (n = 8). ***P < 0.001 control vs PTZ control, ^###P < 0.001 diazepam vs PTZ control, ^aaP < 0.01 and ^aaaP < 0.001 LEV vs PTZ control, ^bP < 0.05 and ^bbP < 0.01 Sod.Se 0.25 vs PTZ control, ^cP < 0.05 and ^ccP < 0.01 Sod.Se 0.5 vs PTZ control. ^ddP < 0.01 and ^dddP < 0.001 LEV + Sod.Se 0.25, ^eeeP < 0.001 and ^eeeeP < 0.0001 LEV + Sod.Se 0.5 vs PTZ control.