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. 2022 Jun 8;79(7):351. doi: 10.1007/s00018-022-04369-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — DNA methylation is an epigenetic barrier to reprogramming in the adult pancreas. Islet transition in the pancreas is dependent on DNA demethylation-mediated reprogramming or dmrE. DNA methylation or 5mC by Dnmt writing enzymes are tightly linked with suppression of the reprogramming genes, Ngn3, and Sox11. The loss of DNA methylation (5C) or demethylation is implicated with multipotency of progenitor (Prog) cells and conversion of a-cells and trans-differentiation into b-like cells in the pancreas