Fig. 1.

Global distribution of inferred CYP2D6 phenotypes. Frequencies of CYP2D6 poor metabolizer (A), intermediate metabolizer (B) and ultrarapid metabolizer (C) phenotypes were calculated based on the frequencies of loss-of-function alleles (*3, *4, *5 and *6), decreased function alleles (*9, *10, *17, *29 and *41) and increased function alleles (*1xN and *2xN) from 53 countries/populations (Tables 1 and 2; Supplementary Table 1). Countries are color-coded with the highest frequency in red, the average frequency across all populations ($\overline{f}$) in yellow, and the lowest frequency in green. In case of missing population frequencies, averaged continent frequency data from the literature (Gaedigk et al. 2017) were used to infer metabolizer phenotypes