Table 2.
Frequencies of decreased (*9, *10, *17, *29 and *41) and increased (duplications) function CYP2D6 alleles across countries/populations
| Country | n | AF, % | |||||
|---|---|---|---|---|---|---|---|
| *9 | *10 | *17 | *29 | *41 | Duplication (*1xN, *2xN) | ||
| Europe | |||||||
| Austria | 93 | 1.6 | 4.3 | 0 | 0 | 12.4 | 1.6 |
| Croatia | 1119–2637 | N/A | N/A | N/A | N/A | 10.8 | 3.4 |
| Denmark | 225–634 | 3.4 | 1.3 | 0 | N/A | 8.4 | 0.8 |
| Estonia | 2373–44,448 | 2 | N/A | N/A | N/A | 5.8 | 0.3 |
| Finland | 56–13,956 | 1.3 | 1.1 | 0 | N/A | 3.2 | 4.3 |
| Germany | 195–1758 | 1.9 | 1.7 | 0 | N/A | 8.4 | 1.3 |
| Greece | 327 | N/A | N/A | N/A | N/A | N/A | 6 |
| Hungary | 55–591 | 1.5 | 1.8 | 0 | 0 | 7.5 | 1.8 |
| Italy | 174–917 | 3 | 1.7 | 2.6 | 0.3 | 0.3 | 15.2 |
| Netherlands | 105 | 3 | N/A | N/A | N/A | 15 | 2.9 |
| Portugal | 1138 | 2.5 | 2.5 | 2.2 | N/A | 6.7 | 3 |
| Russia | 290–1663 | N/A | 4.1 | N/A | N/A | 7.6 | 2.4 |
| Spain | 51–2328 | 2.5 | 1.7 | 0.9 | 0 | 4.7 | 3.5 |
| Sweden | 1816–12,993 | 2.5 | N/A | N/A | N/A | 7.4 | 0.5 |
| Turkey | 100–785 | 0.6 | 7.7 | 1.1 | N/A | N/A | 5.6 |
| Americas | |||||||
| Alaska | 94 | 0 | 4.3 | N/A | N/A | 4.3 | N/A |
| Brazil | 87–1020 | 1.3 | 2.2 | 4.8 | 2.8 | 6.2 | 1.8 |
| Canada | 39–110 | N/A | 3.6 | N/A | N/A | N/A | N/A |
| Columbia | 121 | N/A | N/A | 1.6 | N/A | N/A | N/A |
| Costa Rica | 49–197 | N/A | 0.9 | 4.1 | 2.2 | 3.4 | 3.8 |
| Cuba | 126–130 | N/A | 0.6 | 6.4 | N/A | N/A | N/A |
| Mexico | 74–243 | 0.4 | 2.9 | 0.5 | 0.1 | 1.2 | 2.8 |
| Nicaragua | 98–137 | 4.4 | 3.2 | 0 | N/A | N/A | N/A |
| US | 104,509 | 2.4 | 1.7 | 2.7 | 1.4 | 8.2 | 0.9 |
| US–African American | 6762 | 0.4 | 3.7 | 16.8 | 9.4 | 2.5 | 1 |
| US–Asian | 251 | 0.8 | 9.2 | 0.2 | 0 | 4.4 | 1 |
| US–Caucasian | 37,571 | 2.9 | 1.4 | 0.3 | 0.1 | 9.6 | 0.9 |
| US–Hispanic | 2072 | 1.7 | 1.4 | 1.9 | 1.6 | 5.7 | 0.9 |
| Venezuela | 24–179 | N/A | 3.2 | N/A | N/A | N/A | N/A |
| Africa | |||||||
| Egypt | 145 | N/A | 3.4 | N/A | N/A | 15.1 | N/A |
| Ethiopia | 69–122 | N/A | 8.5 | 11.2 | N/A | 22.9 | N/A |
| Ghana | 193 | 0 | 3.1 | 27.7 | N/A | N/A | N/A |
| Kenya | 195 | N/A | 1 | 20.3 | 15.1 | N/A | 0.5 |
| Zimbabwe | 76–114 | N/A | N/A | 34 | N/A | N/A | N/A |
| East Asia | |||||||
| China | 100–1954 | 0 | 43.4 | 0 | 0 | 3.3 | 0.43 |
| Japan | 86–455 | 0 | 37 | 0 | 0 | 1.3 | 0.8 |
| South Korea | 49–1899 | 0 | 46.9 | 0 | 0 | 1.8 | 0 |
| South Asia | |||||||
| India | 160 | 0 | 5.9 | 0 | 0 | 12.5 | 2.2 |
| Indonesia | 144 | N/A | 28.8 | N/A | N/A | 4.5 | N/A |
| Thai | 920 | N/A | 49.6 | N/A | 0.1 | 6.5 | N/A |
| Vietnam | 136 | N/A | 43.8 | N/A | N/A | N/A | N/A |
| Middle East | |||||||
| Iran | 100 | N/A | 9 | 0 | N/A | N/A | N/A |
| Qatar | 107 | N/A | N/A | N/A | N/A | 15 | N/A |
| Saudi Arabia | 101–192 | N/A | 3 | 3 | 2.9 | 18.4 | 10.4 |
| Syria | 51 | 0 | 2.9 | 0 | N/A | N/A | 7.8 |
| United Arab Emirates | 151 | N/A | 3.3 | 2.5 | 1.6 | 15.2 | 5.9 |
| Oceania | |||||||
| Australia | 5408 | 2.3 | 3.3 | 0.2 | N/A | 10.2 | 1.8 |
| Australia aborigines | 239 | 0 | 0.8 | 0.2 | N/A | N/A | N/A |
| New Zealand | 60 | 0 | 6.1 | N/A | N/A | 3.5 | N/A |
| Papua New Guinea | 84–88 | 0 | 1.5 | 0 | 0 | 0 | 12 |
The corresponding references are provided in Supplementary Table 1
AF allele frequency, n number of individuals genotyped, N/A not available