Table 3.

Frequencies of common functional CYP2C19 alleles across countries/populations

Country	n	AF, %
		*2	*3	*17
Europe
Croatia	1119–1247	15.2	N/A	23.5
Czech Republic	42–265	8	N/A	29
Denmark	69–634	15.8	0	20.1
Estonia	2407–44,448	13.5	0	26.4
Finland	177–13,956	17.5	0	19.6
Germany	60–1758	14.9	1.8	24.9
Greece	283–327	14.1	0	18.2
Hungary	112–591	13.3	0.9	23
Italy	360–917	11.8	0	22.1
Netherlands	428–1158	14.1	0.2	19
Norway	83–403	15.3	0.3	22
Poland	166–791	16.3	N/A	29.8
Portugal	33–400	13.4	0	28.8
Russia	290–1663	13.6	0.3	15
Slovakia	26	19	N/A	33
Spain	78–2328	14	0	17.1
Sweden	110–2020	14	0.5	19.2
Turkey	96–785	11.3	1.8	24
UK	91–168	13.4	N/A	24.2
Americas
Brazil	1034–1212	14.8	0	19.2
Columbia	189–239	8.7	0	17.6
Costa Rica	141	7.1	0	10.3
Cuba	267	10.1	2.6	16.1
Mexico	238	8.6	0	14.3
Nicaragua	212	8.3	N/A	6.8
US	3342	16.5	0.1	20.3
US–African American	250	19.4	0.4	18.2
US–Asian	250	27.6	4.8	6.2
US–Caucasian	250	13.2	0.4	15.8
US–Hispanic	250	12.8	0	15.2
US–Native	50	11	0	9
Venezuela	680	7.3	2.3	N/A
Africa
Egypt	247	11	0.2	N/A
Ethiopia	70–190	13.3	2.3	13.2
Ghana	169	5.9	0	N/A
Morocco	290	11.4	0	N/A
Tanzania	251	17.9	0.6	N/A
Uganda	99	12.6	1	17.2
Zimbabwe	168	4.2	N/A	N/A
East Asia
China	824–5679	29.1	4.4	1.2
Japan	84–1194	30	11.3	1.1
South Korea	271–648	28.3	8.6	1.5
South Asia
India	206–600	35.2	2.4	19.2
Indonesia	96–166	34	6.9	4.7
Thai	1051	27	6	4
Vietnam	100	20.5	2.5	1
Middle East
Iran	82–200	12.9	0.7	21.6
Qatar	108–976	11.6	0.3	20.4
Saudi Arabia	97–201	11.2	0	25.7
Oceania
Australia	5408	16.4	0.2	20.2
Australia aborigines	239	35.5	14.3	N/A
New Zealand	312	18.9	N/A	> 17
Papua New Guinea	172–401	45	16.9	N/A

The corresponding references are provided in Supplementary Table 2

AF allele frequency, n number of individuals genotyped, N/A not available