Table 3.

Elastic Net Results for Three Anxiety Phenotypes: Worry (Measured by PSWQ), Stress (Measured by PSS), and Global Anxiety (Measured by HARS). Showing Significant Resting State Functional Connectivity Measures.

Feature	PSWQ	PSSQ	HARSQ
	Mean β(SD)	Mean β(SD)	Mean β(SD)
PVN - Left Subgenual Anterior Cingulate Cortex	0.33(0.004) *
PVN - Right Parahippocampal Gyrus	0.37(0.004) *
PVN - Bilateral Olfactory Cortex	0.32(0.004) *
Right Amygdala - Right Parahippocampal Gyrus	0.32(0.004) *
Left Amygdala - Right Inferior Temporal Gyrus		−0.15(0.002) *
Left Amygdala - Left Inferior Temporal Gyrus		−0.17(0.002) *
Left Amygdala - Bilateral Fusiform Gyrus		−0.18(0.002) **
Left Amygdala - Left Superior Temporal Gyrus			−0.11(0.001) *

Note.

The results were obtained by building 4 separate elastic net models, one for each anxiety phenotype. Results for Rumination (Measured by RSQ) did not reach statistical significance. We optimized over 50 values of lambda and 10 values of alpha over the range [0–1]. We ran 500 permutations using 5-fold cross validation for each model. P-values were used to assess statistical significance of mean non-zero feature coefficients and were obtained by running a model versus null comparison. Significance levels for p-values: 0.05 = *, 0.01 = **, 0.001 = ***, 0.0001 = ****. β values refer to mean of standardized regression coefficients over runs (n=500), weighed by non-zero frequency over folds (n=5). SD refers to standard deviation of feature coefficients over runs (n=500), weighted by non-zero frequency over folds (n=5). Abbreviations: PSWQ: Penn State Worry Questionnaire. PSS: Perceived Stress Scale. RSQ: Response Styles Questionnaire, HARS: Hamilton Anxiety Rating Scale. PVN: Paraventricular Nucleus.