Table 2.

Univariate Cox proportional hazards regression to determine factors associated with progression-free survival and cancer-specific survival.

	Progression-Free Survival			Cancer-Specific Survival
Predictor	Hazard Ratio	95% CI	p-value	Hazard Ratio	95% CI	p-value
Age at Nephrectomy	1.07	1.01, 1.13	0.022	1.10	1.02, 1.18	0.013
Tumor Size ≤ 7 cm	Ref.	.	.	Ref.	.	.
> 7 cm	5.19	1.73, 15.5	0.003	8.29	2.40, 28.7	0.001
Pathologic Stage pT1	Ref.	.	.	Ref.	.	.
pT2	3.30	0.68, 15.9	0.14	6.89	1.15, 41.3	0.034
pT3	6.45	2.05, 20.3	0.001	14.1	3.36, 58.9	0.0003
Presence of Type 2 Morphology	2.00	0.67, 5.98	0.2	1.64	0.46, 5.81	0.4
Type 2 Morphology (%) (per 10% increase)	1.01	1.00, 1.03	0.084	1.01	1.00, 1.03	0.15
Nuclear Pseudostratification (%)	1.00	0.99, 1.02	0.8	1.00	0.98, 1.02	1
Abundant Eosinophilic and/or Amphophilic Cytoplasm (%)	1.01	1.00, 1.03	0.084	1.02	1.00, 1.04	0.064
Mitotic Rate (/10 HPF)	1.38	1.20, 1.59	<0.0001	1.33	1.21, 1.47	<0.0001
Necrosis (%)	1.01	0.99, 1.03	0.2	1.02	1.00, 1.04	0.12
Sarcomatoid Differentiation (%)	1.08	1.04, 1.12	<0.0001	1.10	1.05, 1.15	<0.0001
Sheet-like Architecture (%)	1.09	1.02, 1.16	0.015	1.10	1.03, 1.18	0.005
LVI	118	31, 445	<0.0001	114	28, 472	<0.0001
Highest WHO/ISUP Grade 1–2	Ref.	.	.	Ref.	.	.
Grade 3–4	1.81	0.63, 5.21	0.3	1.33	0.39, 4.60	0.7
Predominant WHO/ISUP Grade 1–2	Ref.	.	.	Ref.	.	.
Grade 3	4.34	1.36, 13.9	0.013	4.48	1.16, 17.3	0.030
Highest Fuhrman Nuclear Grade 1–2	Ref.	.	.	Ref.	.	.
Grade 3–4	2.43	0.84, 7.02	0.10	3.16	0.91, 10.9	0.069
Predominant Fuhrman Nuclear Grade 1–2	Ref.	.	.	Ref.	.	.
Grade 3	7.13	1.59, 31.9	0.010	9.49	2.01, 44.8	0.004
Capsular Invasion	3.30	1.03, 10.5	0.044	3.06	0.79, 11.8	0.11
Circumscription (%)	0.98	0.96, 0.99	0.003	0.97	0.95, 0.99	0.0002
Tumor Siderophages (%)	1.02	0.98, 1.05	0.4	0.94	0.83, 1.06	0.3
Fibrosis (%)	1.02	0.98, 1.05	0.4	1.03	1.00, 1.06	0.092
Macrophage (%)	0.97	0.94, 1.00	0.058	0.91	0.84, 0.99	0.029