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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2021 Dec 28;149(6):1981–1991. doi: 10.1016/j.jaci.2021.11.025

Table III.

Replication results of variants within the BIRC3 locus with p<0.05 in at least one independent study.

GERA ICS Response GWAS
SNP Ref Alt Alt allele frequency Hazard ratio P-value 1000G EUR panel based r2 1000G cosmopolitan panel based r2
rs12576911 A G 0.275 0.942 0.046 0.921 0.942
GALA II ICS Response GWAS
SNP Ref Alt Alt allele frequency Odds ratio P-value 1000G EUR panel based r2 1000G cosmopolitan panel based r2
rs2604526 C A 0.297 0.752 0.014 0.945 0.687
rs2852880 G C 0.312 0.769 0.022 0.995 0.809
rs2852881 C T 0.312 0.769 0.022 0.995 0.813
rs2852882 T A 0.306 0.771 0.025 0.945 0.792
rs7480738 G T 0.299 0.775 0.029 0.982 0.685
rs2852891 G T 0.306 0.779 0.032 0.928 0.786
rs12787745 C A 0.325 0.790 0.041 0.912 0.759
rs17878708 G A 0.316 0.793 0.045 0.823 0.738
rs150283650 G A 0.340 0.803 0.050 0.921 0.889
SAGE ICS Response GWAS
SNP Ref Alt Alt allele frequency Odds ratio P-value 1000G EUR panel based r2 1000G cosmopolitan panel based r2
rs11606268 C A 0.316 1.385 0.027 0.995 0.936
rs2846857 G A 0.314 1.369 0.034 1.000 0.943
rs11600522 A T 0.318 1.351 0.041 0.995 0.941
rs150283650 G A 0.311 1.350 0.043 0.921 0.889
rs58277500 C G 0.328 1.339 0.046 0.823 0.835
rs12098902 G A 0.322 1.334 0.049 0.921 0.888
rs11602147 C G 0.421 1.304 0.049 0.824 0.790
UK Biobank Asthma GWAS
SNP Ref Alt Alt allele frequency Odds ratio P-value 1000G EUR panel based r2 1000G cosmopolitan panel based r2
rs12280343 T C 0.307 0.974 0.026 0.906 0.880
rs2511293 T C 0.299 0.975 0.032 0.932 0.882
rs3132831 C T 0.299 0.975 0.032 0.932 0.886
rs2604526 C A 0.300 0.975 0.032 0.945 0.687
rs2852891 G T 0.299 0.975 0.032 0.928 0.786
rs2852882 T A 0.300 0.975 0.033 0.945 0.792
rs2846849 G A 0.300 0.975 0.034 0.945 0.894
rs11602147 C G 0.320 0.976 0.038 0.824 0.790
rs2604527 C T 0.299 0.976 0.039 0.945 0.916
rs2846848 G T 0.299 0.976 0.039 0.941 0.891
rs58277500 C G 0.320 0.977 0.042 0.823 0.835
rs17878708 G A 0.318 0.977 0.046 0.823 0.738
rs7480738 G T 0.296 0.977 0.049 0.982 0.685

Hazard ratio and odds ratio use the alternative allele as reference. Pairwise r2 was computed between rs2846858 and the corresponding variant.