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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: SLAS Discov. 2022 Jan 31;27(4):209–218. doi: 10.1016/j.slasd.2022.01.003

Figure 3.

Figure 3.

High content profiler analysis of library screen on iPSC-derived cortical spheroids. (a.) Principal component analysis (PCA), represented as a 3D scatter plot, showing the spatial distribution of sample types including DMSO, stimulatory control (4-AP), inhibitory control (muscimol), and all other compounds. (b.) PCA, represented as a 2D scatter plot, showing the distribution of compounds with mechanisms of action (MOA) of interest in relation to DMSO, 4-AP, and muscimol control compounds. All other compounds are indicated by gray symbols. (c.) Sammon mapping plot displaying groupings of compounds, based on calcium activity after compound exposure, identified by the HCP analysis. All smaller clusters are grouped into three major clusters. (d.) PCA, represented as a 3D scatter plot, showing the spatial distribution of Sammon groupings by color.