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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2022 Jan 11;149(6):2166–2170.e1. doi: 10.1016/j.jaci.2021.12.789

Table 1.

Update of the Food-Induced Systemic Allergic Reaction Grading Scale by the Consortium for Food Allergy Research

Prior CoFAR Grading Scale for Allergic Reactions18
Grade 1 Mild Grade 2 Moderate Grade 3 Severe Grade 4 Life-threatening Grade 5 Death
Transient or mild discomforts (<48 hours), no or minimal medical intervention/therapy required. These symptoms may include pruritus, swelling or rash, abdominal discomfort or other transient symptoms. Symptoms that produce mild to moderate limitations in activity some assistance may be needed; no or minimal intervention/therapy is required. Hospitalization is possible. These symptoms may include persistent hives, wheezing without dyspnea, abdominal discomfort / increased vomiting of other symptoms Marked limitation in activity, some assistance usually required; medical intervention/therapy required; hospitalization is possible. Symptoms may include bronchospasm with dyspnea, severe abdominal pain, throat tightness with hoarseness, transient hypotension among others. Parenteral medication(s) are usually indicated. Extreme limitation in activity, significant assistance required; significant medical/therapy. Intervention is required; hospitalization is probable. Symptoms may include persistent hypotension and/or hypoxia with resultant decreased level of consciousness associated with collapse or other life-threatening symptoms. Death