Table 4:

Similarities and major differences between available grading scales

Prior CoFAR	Current CoFAR (V3)	WAO 201722	Dribin et al16
Specifically designed for food-induced allergic reactions Grades determined mainly by limitation in activity and intervention required Limited examples of signs/symptoms given for each grade, but not comprehensive Great deal of investigator discretion allowed in determining severity	Specifically designed for food-induced allergic reactions Grades broken down by number and type of organ system(s) involved, as well as severity of symptoms Signs/symptoms for each grade provided in far more detail than in CoFAR V1 Investigator discretion in assigning grade minimized	Update of WAO 2010 grading system Designed for reactions due to all triggers, but primarily utilized for subcutaneous immunotherapy Similar to CoFAR V3 with a few major differences (e.g. isolated abdominal cramps or vomiting Grade 3 in WAO but Grade 1 in CoFAR V3 until there are changes in activity level)	Very specific grading scale, broken down by number and type of organ system(s), as well as symptom severity Includes detailed subgrading system based on clinical criteria Designed for generalizability (e.g in the emergency department, rather than specifically for food-induced reactions