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. 2022 Jun 9;13(6):539. doi: 10.1038/s41419-022-04949-9

Fig. 2. Effects of exosomal circRNAs on immune checkpoints and T cells.

Fig. 2

CircRNAs sponge specific miRNAs as they enter cancer cells or T cells, increasing PDL1/PD1 expression. After PD1 was combined with PDL1, the activity and proliferation of T cells decreased significantly.