Table 1.
The role of exosomal circRNAs in tumour immunity.
| Cancer types | Source cell | Exosomal circRNA | Receptor cells | Molecular axis | Functions | Result |
|---|---|---|---|---|---|---|
| Oesophageal squamous cell carcinoma | Cancer cell | Circ0048117 | Macrophages | circ0048117/miR-140/TLR4 | M1-M2 | Immune escape |
| Non-small cell lung cancer | CircFARSA | circFARSA/PTEN/PI3K/AKT | ||||
| Hepatocellular carcinoma | Circ0074854 | |||||
| Glioma | CircNEIL3 | CircNEIL3/IGF2BP3/YAP1 | ||||
| Colorectal cancer | CircPACRGL | Neutrophil | circPACRGL/miR-142-3p/miR-506-3p-TGF-β1 | N1-N2 | ||
| Hepatocellular carcinoma | CircUHRFI | NK cell | circUHRF1/miR-449c-5p/TIM-3 | NK Cell Exhaustion | ||
| Ovarian cancer | Circ0001068 | T cell | circ0001068/miR-28-5P/PD1 | T cell apoptosis, disintegration, inhibition of proliferation | ||
| Non-small cell lung cancer | CircUSP7 | circUSP7/miR-934/SHP2 | ||||
| Lung adenocarcinoma | CircRNA-002178 | circRNA-002178/miR-28-5P/PD1 | ||||
| Cancer cell | circRNA-002178/miR-34/PDL1 | |||||
| Colorectal cancer | Cancer-associated fibroblast | CircEIF3K | circEIF3K/miR-214/PDL1 |