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. Author manuscript; available in PMC: 2022 Nov 2.
Published in final edited form as: Nat Metab. 2022 May 2;4(5):627–643. doi: 10.1038/s42255-022-00566-0

Extended Data Fig. 3. Energy status regulates astrocytic glutamate uptake at VMH synapses via BDNF signaling.

Extended Data Fig. 3

a. Representative traces of raw NMDAR responses (light purple), responses +100 uM DL-TBOA (dark purple), and responses + 50 uM APV (light gray). For following panels, Fed + aCSF (n = 6), Fasted + aCSF (n = 7), Fasted + BDNF (n = 6)

b. Amplitude (pA) of NMDAR responses before and after DL-TBOA application.

c. Charge transfer (pA*ms) of NMDAR responses before and after DL-TBOA application.

d. Decay (weighted tau) of NMDAR responses before and after DL-TBOA application. Two-way ANOVA: Condition, p = 0.007; DL-TBOA, p = 0.02; Interaction of condition and DL-TBOA, p = 0.0009. Bonferroni multiple comparisons, *, p < 0.0001.

Data represented as mean +/− SEM