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. Author manuscript; available in PMC: 2022 Nov 2.
Published in final edited form as: Nat Metab. 2022 May 2;4(5):627–643. doi: 10.1038/s42255-022-00566-0

Extended Data Fig. 1. Intrinsic excitability of VMH neurons is not regulated by energy status or BDNF signaling.

Extended Data Fig. 1

a. Amplitude of sEPSCs in VMH neurons of fed (n = 21) and fasted WT (n = 21) and fed BDNF2L/2LCK:Cre mice (n = 19) (4 – 6 mice per group), Ordinary One-way ANOVA, p = 0.3

b. Amplitude of sEPSCs in VMH neurons of in WT Fed + aCSF (n = 13), Fasted + aCSF (n = 13) and Fasted + BDNF conditions (n = 12) (4 mice per group), Ordinary One-way ANOVA, p = 0.136

c. Input-output curves from VMH neurons in fed (n = 19) and fasted WT (n = 18) and fed BDNF2L/2LCK-Cre mice (n = 17) (3 - 4 mice per group). Two-way repeated measures ANOVA: Interaction, p = 0.7; Genotype, p = 0.3.

d. Representative Traces showing resulting hyperpolarization or evoked action potentials in response to current injection steps of −120 mV and 120 mV.

Data represented as mean +/− SEM