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. Author manuscript; available in PMC: 2022 Nov 2.
Published in final edited form as: Nat Metab. 2022 May 2;4(5):627–643. doi: 10.1038/s42255-022-00566-0

Extended Data Fig. 2. Energy status and BDNF regulate astrocytic glutamate uptake at VMH synapses.

Extended Data Fig. 2

a. Representative traces of raw NMDAR responses (light purple), responses +100 uM DL-TBOA (dark purple), and responses + 50 uM APV (light gray). For following panels, WT Fed (n = 8), WT Fasted (n = 7), and Fed BDNF 2L/2L CK:Cre (n = 10)

b. Amplitude (pA) of NMDAR responses before and after DL-TBOA application.

c. Charge transfer (pA*ms) of NMDAR responses before and after DL-TBOA application.

d. Decay (weighted tau) of NMDAR responses before and after DL-TBOA application. Two-way ANOVA: Genotype, p = 0.01; p = 0.0005; Interaction of genotype and DL-TBOA, p = 0.09. Bonferroni multiple comparisons, *, p = 0.001.

Data represented as mean +/− SEM