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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Mol Cell Neurosci. 2022 Mar 24;120:103722. doi: 10.1016/j.mcn.2022.103722

Fig. 3. Proposed mechanisms of aminoglycoside entry into the endolymph.

Fig. 3.

Aminoglycoside (AG) is detected in the capillaries [1] and individual cell subtypes [2] in the stria vascularis. In vivo work showed that AG enters into endolymph [3]. AG uptake into the perilymph has also been suggested [4]. Reissner’s and basilar membranes (RM and BM) are also considered as possible entry routes of AG from the perilymph to the endolymph [5]. Thick arrows indicate the AG entry routes with stronger evidences than narrow arrows. SV, scala vestibuli; SM, scala media; ST, scala tympani; StV, stria vascularis; SL, spiral ligament; SpL, spiral limbus; OSL, osseous spital lamina; SGN, spiral ganglion neuron; NF, nerve fiber.