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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Mol Cell Neurosci. 2022 Mar 24;120:103722. doi: 10.1016/j.mcn.2022.103722

Fig. 5. Intracellular mechanism of aminoglycoside toxicity in hair cells.

Fig. 5.

A simplified schematic of the effect of aminoglycosides (AG) in hair cells. AG interacts with organelles like mitochondria, ribosomes and endoplasmic reticulum, triggering reactive oxygen species production. Excess of reactive oxygen species within the cells can trigger hair cell death. Interaction of AGs with the lipid bilayer components like PIP2 can render the hair cells nonfunctional.